News

The application of titanium materials in the pharmaceutical industry

The pharmaceutical industry is an important industry related to people's physical and mental health, including pharmaceuticals, medical machinery, sanitary materials, and other fields, occupying an important position in the national economy. Titanium is widely used in the pharmaceutical industry due to its non-toxic and harmless properties, as well as its good compatibility with the human body.

In pharmaceutical production, as the production of drugs cannot be separated from acids, bases, and salts, pharmaceutical equipment is easily corroded and damaged. The use of steel equipment not only fails to solve the problem of severe equipment corrosion, but also causes significant losses in manpower, material resources, and financial resources, affecting normal production. The use of titanium equipment effectively solves this problem.

In the production of several commonly used drugs, equipment made of titanium materials has good corrosion resistance and has achieved considerable economic benefits.

1. Vitamin B1 production

In China, the hydrogen chloride conversion method is commonly used to produce vitamin B1, and the finished product is dried by cyclone and separated twice by cyclone. Its medium is thiamine hydrochloride, with a pH value of 2.5 and a temperature of 110 ℃, making it highly corrosive. The original drying device was made of stainless steel material, and after more than a year of use, the inner wall corroded and perforated, seriously contaminating the medicine.

After using a titanium screw feeder, cyclone separator, vortex body, hopper and discharge pipe, and tail gas box titanium lining, the production qualification rate of vitamin B1 has increased from the highest 95% to 100%, and the equipment has been used for more than 7 years without corrosion. The titanium cost can be recovered in 3 months.

2. Vitamin C production

Vitamin C is made from sorbitol as raw material, fermented into sorbitol by black vinegar bacteria, and then fermented with Pseudomonas to produce low concentration gulonic acid. After concentration, it is converted into a finished product by hydrogen chloride.

Titanium is highly resistant to corrosion in high-temperature acid. In the production process of this product, titanium tube heat exchangers, titanium DHC-500 disc settling automatic slag removal centrifuges, and TC4 cast impellers were used, and no corrosion was found after years of use.

3. Antibiotic production

The main raw material for the chemical synthesis of chloramphenicol (an antibiotic) is methyl dichloroacetate, which contains about 2% chlorinated ene and trichloroethylene. If steel equipment is used in the refining process, serious corrosion is prone to occur. After switching to titanium equipment, it remains intact to this day.

4. Anesthetic production

The production of procaine hydrochloride used for local anesthesia uses p-nitrotoluene as the raw material, and there is strong corrosiveness in the entire production process of oxidation to produce p-nitrobenzoic acid, acetic acid washing, and mother liquor recovery. Therefore, the production equipment adopts titanium steel composite plate inner cylinder, titanium bubble tube, ice acetic acid circulation condenser, and vapor-liquid separator to solve the corrosion problem.

5. Insecticides and other pharmaceutical production

Qusujing (Tetraimidazole) is an efficient intestinal nematode repellent. In the production of this product, stainless steel equipment was originally used, but corrosion caused product contamination. After using titanium as the feed pipe and pump inlet pipe, the corrosion problem was successfully solved.

Nitrochlorophenol is a specific veterinary drug for treating liver fluke in cattle and sheep, produced using sulfuric acid, nitric acid, glacial acetic acid, and chlorine containing solutions. The mixer is made of titanium and has been running normally so far. In addition, activated carbon decolorization is commonly used in pharmaceutical production. After replacing stainless steel suction filters with titanium suction filters, they remain intact even after 9 years of use.

In the production of brominated amino acids abroad, titanium reactors are used for bromination, separation, salting out, extraction, and distillation processes. It is necessary to use titanium equipment for the production of malaria drugs, anti schistosomiasis drugs that come into contact with chloride ions, contraceptive pills, rheumatic drugs, etc. using quinoline derivatives in China. Other options such as penicillin esterification reactors, saccharification tanks, chloramphenicol film evaporators, acetaminophen reactors, Mitol filters, dimethyl sulfate coolers, and liquid filters all have the feasibility and necessity of using titanium materials for manufacturing.

[ 上一页 ] The application fi...[ 下一页 ] Titanium alloy 3D ...